Team Leader
Mark Viant
Professor of Metabolomics
Professor Mark Viant’s expertise lies predominantly in the field of metabolomics. His research interests span from method development in analytical chemistry and bioinformatics through to the application of metabolomics to both human and environmental toxicology, focusing extensively on finding novel solutions for industry and regulators in chemical safety science.
Jacob-Joe Collins
2020-2024 BBSRC iCASE with Unilever
Integrating Mass Spectrometry and Bioinformatics to Develop Physiology-Based Kinetic Models for Chemical Safety Science
1. Build a one-compartment toxicokinetic model using available literature data for the model species Daphnia magna (water flea).
2. Evaluate the uptake of chemicals within Daphnia magna over time, using mass spectrometry approaches and microdissection.
3. Conduct toxicokinetic studies to discover the biotransformation products of chemicals within Daphnia magna.
4. Develop a deployable physiologically based kinetic model for Daphnia magna parameterised and validated using data and knowledge derived from objectives 1-3.