We study how the immune system attacks invading pathogens – and why it sometimes goes wrong.  We’re particularly interested in microbes that evade or hijack the human immune system.  You can learn more about our ERC-funded project to discover more about pathogen evolution on our MitoFun page.

On the right, the fatal fungus Cryptococcus neoformans is escaping from a macrophage (a type of white blood cell) by a process called vomocytosis.  Below, you can see the macrophages response – ‘actin flashes’ that act to trap the fungus inside the immune cell.