‘Vomocytosis’, the process by which live pathogens are expelled from macrophages. A J774 macrophage has internalised cryptococci (the round “balls”). It tries to kill the fungus by depositing “killer granules” known as lysosomes (marked in red) into the phagosome. When the macrophage fails to kill its prey, then the pathogen is suddenly expelled. This expulsion also provides a route for direct transmission of the pathogen to a neighbouring cell (click here for the paper about this process or here to see the movies).