{"id":10,"date":"2017-11-13T16:25:30","date_gmt":"2017-11-13T16:25:30","guid":{"rendered":"https:\/\/more.bham.ac.uk\/mitofun\/?page_id=10"},"modified":"2019-05-22T12:02:27","modified_gmt":"2019-05-22T11:02:27","slug":"index","status":"publish","type":"page","link":"https:\/\/more.bham.ac.uk\/mitofun\/","title":{"rendered":"MitoFun"},"content":{"rendered":"

\"\"The Mitofun project<\/a> looks at M<\/span>ITO<\/span><\/strong>chondria as regulators of F<\/span>UN<\/span><\/strong>gal virulence.\u00a0 Mitochondria is a network within a cell where it\u2019s energy is generated.\u00a0 The project aims to discover how mitochondrial function and their ability to change shape and structure regulate the virulence of fungal pathogens.<\/p>\n

\"\"

This is a microscopic image of a yeast cell C. gattii<\/em> expressing mitochondrial marker HEM15 tagged with a green fluorescent protein (green signal represents mitochondria).<\/p><\/div>\n

Fungal diseases represent a significant and growing threat to human health.\u00a0 Worldwide, 1.5 million people are thought to die of invasive fungal infections such as candidiasis<\/em>, cryptococcosis<\/em> or aspergillosis<\/em> every year.<\/p>\n

We need to understand how fungal virulence evolves in order to guide future therapies and inform fundamental research. We believe that a key regulator of fungal virulence in animal hosts is the activity of the fungal mitochondria.\u00a0 By combining genetic and cell biological approaches together with a high-resolution imaging and animal infection model,\u00a0 we aim to prove this theory which will revolutionise our understanding and treatment of fungal diseases in a wide variety of hosts.<\/p>\n

This \u00a31.5 million pioneering project, is funded by the European Union\u2019s 7th Framework Programme through the European Research Council. Based in Professor Robin May\u2019s lab at the University of Birmingham, UK, Mitofun<\/a> began in 2014 and over the next 6 years will work with a number of international collaborators to achieve it\u2019s aims. \u00a0For further information please do get in touch.<\/a><\/p>\n

This project is funded by the European Research Council under the European Union\u2019s Framework 7 Programme (FP\/2007-2013)\/ERC Grant Agreement No. 614562<\/span><\/h6>\n\"\"\"\"\n","protected":false},"excerpt":{"rendered":"

The Mitofun project looks at MITOchondria as regulators of FUNgal virulence.\u00a0 Mitochondria is a network within a cell where it\u2019s energy is generated.\u00a0 The project aims to discover how mitochondrial function and their ability to change shape and structure regulate the virulence of fungal pathogens. Fungal diseases represent a significant and growing threat to human… Read more »<\/a><\/p>\n","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-10","page","type-page","status-publish","hentry"],"featured_image_urls_v2":{"full":"","thumbnail":"","medium":"","medium_large":"","large":"","1536x1536":"","2048x2048":"","bones-thumb-600":"","bones-thumb-300":"","promobox":"","ab-block-post-grid-landscape":"","ab-block-post-grid-square":"","post-thumbnail":""},"post_excerpt_stackable_v2":"

The Mitofun project looks at MITOchondria as regulators of FUNgal virulence.\u00a0 Mitochondria is a network within a cell where it\u2019s energy is generated.\u00a0 The project aims to discover how mitochondrial function and their ability to change shape and structure regulate the virulence of fungal pathogens. This is a microscopic image of a yeast cell C. gattii expressing mitochondrial marker HEM15 tagged with a green fluorescent protein (green signal represents mitochondria). Fungal diseases represent a significant and growing threat to human health.\u00a0 Worldwide, 1.5 million people are thought to die of invasive fungal infections such as candidiasis, cryptococcosis or aspergillosis every…<\/p>\n","category_list_v2":"","author_info_v2":{"name":"Simon Levermore","url":"https:\/\/more.bham.ac.uk\/mitofun\/author\/levermsj\/"},"comments_num_v2":"0 comments","featured_image_src":null,"featured_image_src_square":null,"_links":{"self":[{"href":"https:\/\/more.bham.ac.uk\/mitofun\/wp-json\/wp\/v2\/pages\/10","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/more.bham.ac.uk\/mitofun\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/more.bham.ac.uk\/mitofun\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/more.bham.ac.uk\/mitofun\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/more.bham.ac.uk\/mitofun\/wp-json\/wp\/v2\/comments?post=10"}],"version-history":[{"count":9,"href":"https:\/\/more.bham.ac.uk\/mitofun\/wp-json\/wp\/v2\/pages\/10\/revisions"}],"predecessor-version":[{"id":153,"href":"https:\/\/more.bham.ac.uk\/mitofun\/wp-json\/wp\/v2\/pages\/10\/revisions\/153"}],"wp:attachment":[{"href":"https:\/\/more.bham.ac.uk\/mitofun\/wp-json\/wp\/v2\/media?parent=10"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}