{"id":1741,"date":"2021-08-26T16:57:44","date_gmt":"2021-08-26T15:57:44","guid":{"rendered":"https:\/\/more.bham.ac.uk\/hidalgo\/?page_id=1741"},"modified":"2021-10-14T12:37:08","modified_gmt":"2021-10-14T11:37:08","slug":"neurogenic-glia","status":"publish","type":"page","link":"https:\/\/more.bham.ac.uk\/hidalgo\/neurogenic-glia\/","title":{"rendered":"Neurogenic glia"},"content":{"rendered":"\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"Regenerative Neurogenic Response From Glia Requires Insulin driven Neuron glia Communication\" width=\"1200\" height=\"675\" src=\"https:\/\/www.youtube.com\/embed\/254nSAt9Tzc?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<p>Understanding how injury to the central nervous system induces de novo neurogenesis in animals would help promote regeneration in humans. Regenerative neurogenesis could originate from glia and glial neuron-glia antigen-2 (NG2) may sense injury-induced neuronal signals, but these are unknown. Here, we used&nbsp;<em>Drosophila<\/em>&nbsp;to search for genes functionally related to the&nbsp;<em>NG2<\/em>&nbsp;homologue&nbsp;<em>kon-tiki (kon),<\/em>&nbsp;and identified&nbsp;<em>Islet Antigen-2 (Ia-2),<\/em>&nbsp;required in neurons for insulin secretion. Both loss and over-expression of&nbsp;<em>ia-2<\/em>&nbsp;induced neural stem cell gene expression, injury increased&nbsp;<em>ia-2<\/em>&nbsp;expression and induced ectopic neural stem cells. Using genetic analysis and lineage tracing, we demonstrate that Ia-2 and Kon regulate&nbsp;<em>Drosophila<\/em>&nbsp;insulin-like peptide 6 (Dilp-6) to induce glial proliferation and neural stem cells from glia. Ectopic neural stem cells can divide, and limited de novo neurogenesis could be traced back to glial cells. Altogether, Ia-2 and Dilp-6 drive a neuron-glia relay that restores glia and reprogrammes glia into neural stem cells for regeneration.<\/p>\n\n\n\n<p>To find out more, read:<\/p>\n\n\n\n<p>Harrison N,&nbsp;Connolly E,&nbsp;Gasc\u00f3n&nbsp;Gubieda A,&nbsp;Yang Z,&nbsp;Altenhein B,&nbsp;Losada-Perez M,&nbsp;Moreira&nbsp;M,&nbsp;Hidalgo A (2021)&nbsp;Regenerative neurogenesis is induced from glia by Ia-2 driven neuron-glia communication.&nbsp;<strong><em>eLife<\/em><\/strong>10:e58756&nbsp;DOI:&nbsp;<a href=\"https:\/\/doi.org\/10.7554\/eLife.58756\">10.7554\/eLife.58756<\/a><\/p>\n\n\n\n<p>Funded by BBSRC.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"263\" height=\"100\" src=\"https:\/\/more.bham.ac.uk\/hidalgo\/wp-content\/uploads\/sites\/26\/2018\/07\/new-bbsrc-colour-1.jpg\" alt=\"\" class=\"wp-image-317\"\/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Understanding how injury to the central nervous system induces de novo neurogenesis in animals would help promote regeneration in humans. Regenerative neurogenesis could originate from glia and glial neuron-glia antigen-2 (NG2) may sense injury-induced neuronal signals, but these are unknown. Here, we used&nbsp;Drosophila&nbsp;to search for genes functionally related to the&nbsp;NG2&nbsp;homologue&nbsp;kon-tiki (kon),&nbsp;and identified&nbsp;Islet Antigen-2 (Ia-2),&nbsp;required in &#8230; <a title=\"Neurogenic glia\" class=\"read-more\" href=\"https:\/\/more.bham.ac.uk\/hidalgo\/neurogenic-glia\/\" aria-label=\"More on Neurogenic glia\">Read more<\/a><\/p>\n","protected":false},"author":73,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1741","page","type-page","status-publish"],"featured_image_urls_v2":{"full":"","thumbnail":"","medium":"","medium_large":"","large":"","1536x1536":"","2048x2048":"","ab-block-post-grid-landscape":"","ab-block-post-grid-square":""},"post_excerpt_stackable_v2":"<p>Understanding how injury to the central nervous system induces de novo neurogenesis in animals would help promote regeneration in humans. Regenerative neurogenesis could originate from glia and glial neuron-glia antigen-2 (NG2) may sense injury-induced neuronal signals, but these are unknown. Here, we used&nbsp;Drosophila&nbsp;to search for genes functionally related to the&nbsp;NG2&nbsp;homologue&nbsp;kon-tiki (kon),&nbsp;and identified&nbsp;Islet Antigen-2 (Ia-2),&nbsp;required in neurons for insulin secretion. Both loss and over-expression of&nbsp;ia-2&nbsp;induced neural stem cell gene expression, injury increased&nbsp;ia-2&nbsp;expression and induced ectopic neural stem cells. Using genetic analysis and lineage tracing, we demonstrate that Ia-2 and Kon regulate&nbsp;Drosophila&nbsp;insulin-like peptide 6 (Dilp-6) to induce glial proliferation and neural stem&hellip;<\/p>\n","category_list_v2":"","author_info_v2":{"name":"hidalgoa","url":"https:\/\/more.bham.ac.uk\/hidalgo\/author\/hidalgoa\/"},"comments_num_v2":"0 comments","featured_image_src":null,"featured_image_src_square":null,"_links":{"self":[{"href":"https:\/\/more.bham.ac.uk\/hidalgo\/wp-json\/wp\/v2\/pages\/1741","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/more.bham.ac.uk\/hidalgo\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/more.bham.ac.uk\/hidalgo\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/more.bham.ac.uk\/hidalgo\/wp-json\/wp\/v2\/users\/73"}],"replies":[{"embeddable":true,"href":"https:\/\/more.bham.ac.uk\/hidalgo\/wp-json\/wp\/v2\/comments?post=1741"}],"version-history":[{"count":13,"href":"https:\/\/more.bham.ac.uk\/hidalgo\/wp-json\/wp\/v2\/pages\/1741\/revisions"}],"predecessor-version":[{"id":2181,"href":"https:\/\/more.bham.ac.uk\/hidalgo\/wp-json\/wp\/v2\/pages\/1741\/revisions\/2181"}],"wp:attachment":[{"href":"https:\/\/more.bham.ac.uk\/hidalgo\/wp-json\/wp\/v2\/media?parent=1741"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}